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Carriage of serogroup W-135, ET-37 meningococci in The Gambia: implications for immunisation policy?

Authors
  • MacLennan, J M
  • Urwin, R
  • Obaro, S
  • Griffiths, D
  • Greenwood, B
  • Maiden, M C
Type
Published Article
Journal
The Lancet
Publisher
Elsevier BV
Publication Date
Sep 23, 2000
Volume
356
Issue
9235
Pages
1078–1078
Identifiers
PMID: 11009146
Source
Medline
Keywords
License
Unknown

Abstract

We found high levels of symptomless carriage of a hyperinvasive Neisseria meningitidis strain (electrophoretic type 37 [ET-37], serogroup W-135) during a vaccine trial in Gambian children in 1996. Serogroup C, ET-37 complex meningococci cause 30-40% of meningococcal disease in countries such as the UK, and have a point prevalence of 0.5-1.0%. The recent Haj-associated spread of serogroup W-135, ET-37 complex meningococci, which has been accompanied by numerous secondary cases, might be explained by the apparently raised carriage rates reported here.

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