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Carpal tunnel syndrome. A new feature in the natural history of TOS?

Authors
  • Estirado de Cabo, Eva1
  • Posada de la Paz, Manuel1
  • de Andrés Copa, Pilar1
  • del Mar Plaza Cano, Mar1
  • García de Aguinaga, Marisa L.1
  • Suarez Álvarez, Carmen1
  • Braun Saro, Beatriz1
  • 1 Carlos III Institute of Public Health, Toxic Oil Syndrome and Rare Disease Research Center, Madrid, Spain , Madrid
Type
Published Article
Journal
European Journal of Epidemiology
Publisher
Springer-Verlag
Publication Date
Oct 01, 2003
Volume
18
Issue
10
Pages
983–993
Identifiers
DOI: 10.1023/A:1025899506009
Source
Springer Nature
Keywords
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Abstract

Objective: To ascertain whether carpal tunnel syndrome (CTS) in patients affected with toxic oil syndrome (TOS) is associated with conditions and diseases considered risk factors for CTS in the general population and/or with certain clinical manifestations of TOS. Methods: We conducted a case–control study to compare 89 TOS patients residing in Madrid diagnosed with CTS from 1981 through July 2001 (cases) against 638 TOS patients not affected with CTS (controls). Risk factors for CTS and clinical manifestations of TOS were analyzed. Results: Multivariate logistic regression analysis yielded the following odds ratios (95% confidence interval): 3.32 (1.47–7.50) for TOS-related neuropathy; 2.85 (1.14–7.13) for TOS-related thromboembolic events; 2.63 (1.36–5.06) for female gender; 0.43 (0.24–0.80) for TOS-related scleroderma; 0.26 (0.12–0.59) for smoking; and, in women, 2.53 (1.06–5.70) for fibrositis and 1.84 (1.04–3.20) for miscarriages. Conclusion: Our study findings support the hypothesis that CTS in TOS patients is more linked to certain clinical manifestations of TOS, mainly neuropathy, than to conditions and diseases considered risk factors for CTS in the general population.

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