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Carotid Bifurcation With Tandem Stenosis—A Patient-Specific Case Study Combined in vivo Imaging, in vitro Histology and in silico Simulation

Authors
  • Wang, Jiaqiu1
  • Paritala, Phani Kumari1
  • Mendieta, Jessica Benitez1
  • Gu, Yuantong1
  • Raffel, Owen Christopher2, 3
  • McGahan, Tim4
  • Lloyd, Thomas5
  • Li, Zhiyong1, 6
  • 1 School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD , (Australia)
  • 2 Department of Cardiology, The Prince Charles Hospital, Brisbane, QLD , (Australia)
  • 3 School of Medicine, University of Queensland, Brisbane, QLD , (Australia)
  • 4 Department of Vascular Surgery, Princess Alexandra Hospital, Brisbane, QLD , (Australia)
  • 5 Department of Radiology, Princess Alexandra Hospital, Brisbane, QLD , (Australia)
  • 6 School of Biological Science & Medical Engineering, Southeast University, Nanjing , (China)
Type
Published Article
Journal
Frontiers in Bioengineering and Biotechnology
Publisher
Frontiers Media SA
Publication Date
Nov 20, 2019
Volume
7
Identifiers
DOI: 10.3389/fbioe.2019.00349
PMID: 31824937
PMCID: PMC6879432
Source
PubMed Central
Keywords
License
Unknown

Abstract

A patient-specific carotid bifurcation with tandem stenosis found at both internal carotid artery (ICA) and common carotid artery (CCA) was studied. The in vivo pre-carotid endarterectomy (pre-CEA) multi-spectral magnetic resonance imaging (MRI) were performed and in vitro post-CEA carotid plaque tissue sample was collected. MR imaging data and tissue sample staining histology were used to recognize the plaque components. Further, the computational fluid dynamics (CFD) were performed on four MR-based reconstructed 3D carotid bifurcation models (the patient-specific geometry with tandem stenosis and three presumptive geometries by removing the stenosis part). The flow and shear stress behavior affected by the tandem stenosis was analyzed. From the results of MR segmentation and histology analysis, plaque lipid pool and calcification were found at both ICA and CCA. From the result of CFD simulation, the flow shear stress behavior suggested the tandem stenosis as a more “dangerous” situation than a single-stenosis artery. Besides, the CFD results deduced that the stenosis at the CCA location formed initially and led to the subsequent formation of stenosis at ICA. This study suggests that when planning CEA, CFD simulation on the presumptive models could help clinicians to estimate the blood flow behavior after surgery. Particular attention should be paid to the case of tandem stenosis, as the local hemodynamic environment is more complex and treatment of one stenosis may lead to a variation in the hemodynamic loading on the second plaque, which may result in either a higher risk of plaque rupture or restenosis.

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