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Carnitine and creatine content of tissues of normal and alloxan-diabetic sheep and rats.

Authors
  • Henderson, G D
  • Xue, G P
  • Snoswell, A M
Type
Published Article
Journal
Comparative biochemistry and physiology. B, Comparative biochemistry
Publication Date
Jan 01, 1983
Volume
76
Issue
2
Pages
295–298
Identifiers
PMID: 6641161
Source
Medline
License
Unknown

Abstract

The concentration of carnitine in liver increased 28-fold and urinary carnitine excretion 5-fold in alloxan-diabetic sheep. In contrast there were no similar increases in alloxan-diabetic rats. The creatine content of liver decreased 3-fold and creatine excretion decreased 2-fold in diabetic sheep. In contrast the creatine content of liver increased nearly 4-fold in diabetic rats with no change in creatine excretion. The marked increased in production of carnitine by the liver of the diabetic sheep appears possible because of decreased production and excretion of creatine.

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