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Cardiovascular sequelae of therapeutic thoracic radiation.

Authors
  • Arsenian, M A
Type
Published Article
Journal
Progress in cardiovascular diseases
Publication Date
Jan 01, 1991
Volume
33
Issue
5
Pages
299–311
Identifiers
PMID: 2003146
Source
Medline
License
Unknown

Abstract

Mediastinal radiation damages endothelial cells, with resulting loss of capillaries and ischemia at the level of the microcirculation. These changes lead to increases in collagen and proliferation of fibrous tissue throughout the heart. Cardiac dysfunction following radiotherapy is surprisingly common and may be due to pericardial, myocardial, valvular, conduction system, or coronary artery disease. Greater awareness of cardiotoxicity has prompted changes in radiation techniques that appear to reduce clinical cardiovascular complications.

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