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Cardiovascular manifestations and cardiac magnetic resonance follow-up of multisystem inflammatory syndrome in children (MIS-C).

  • Karagözlü, Selen1
  • Ramoğlu, Mehmet G1
  • Bayram, Özlem1
  • Bakhtiyarzada, Jeyhun1
  • Aydın, Alperen1
  • Yılmaz, Mehmet Mustafa1
  • Murt, Begüm1
  • Özkan, Ersin2
  • İnceli, Hatice Belkıs3
  • Gurbanov, Anar4
  • Şükriye, Yılmaz5
  • Demir, Berrin5
  • Özdemir, Halil3
  • Çiftçi, Ergin3
  • Kendirli, Tanıl4
  • Uçar, Tayfun1
  • Fitoz, Ömer Suat5
  • Tutar, Ercan1
  • 1 Ankara University, School of Medicine, Department of Pediatric Cardiology, Ankara, Turkey. , (Turkey)
  • 2 Ankara University, School of Medicine, Department of Pediatrics, Ankara, Turkey. , (Turkey)
  • 3 Ankara University, School of Medicine, Department of Pediatric Infectious Diseases, Ankara, Turkey. , (Turkey)
  • 4 Ankara University, School of Medicine, Department of Pediatric Intensive Care, Ankara, Turkey. , (Turkey)
  • 5 Ankara University, School of Medicine, Department of Pediatric Radiology, Ankara, Turkey. , (Turkey)
Published Article
Cardiology in the Young
Cambridge University Press
Publication Date
Feb 01, 2024
DOI: 10.1017/S1047951123001348
PMID: 37381829


This study aimed to evaluate the cardiovascular manifestations and surveillance of multisystem inflammatory syndrome in children (MIS-C) and to determine the correlation of echocardiographic findings with cardiac magnetic resonance imaging findings. Forty-four children diagnosed as MIS-C with cardiac involvement were enrolled in this observational descriptive study. The diagnosis of MIS-C was made according to the criteria of Centers for Disease Control and Prevention. Clinical findings, laboratory parameters, and electrocardiographic and echocardiographic findings at the time of diagnosis and during follow-up were evaluated. Cardiac magnetic resonance was performed on 28 (64%) cases. The 1-year follow-up imaging was performed in all cases with abnormal initial cardiac magnetic resonance findings. Forty-four patients (56.8% male) with a mean age of 8.5 ± 4.8 years were enrolled in this study. There was a significant positive correlation between high-sensitivity cardiac troponin T (mean: 162 ± 444.4 pg/ml) and N-terminal pro b-type natriuretic peptide (mean: 10,054 ± 11,604 pg/ml) (p < 0.01). Number of cases with an electrocardiographic and echocardiographic abnormality was 34 (77%) and 31 (70%), respectively. Twelve cases (45%) had left ventricular systolic dysfunction and 14 (32%) cases had pericardial effusion on admission. Three cases (11%) had cardiac magnetic resonance findings that may be attributed to the presence of myocardial inflammation, and pericardial effusion was present in seven (25%) cases. Follow-up cardiac magnetic resonances of all cases were normal. Cardiac abnormalities were completely resolved in all except two cases. Myocardial involvement can be seen during acute disease, but MIS-C generally does not lead to prominent damage during a year of surveillance. Cardiac magnetic resonance is a valuable tool to evaluate the degree of myocardial involvement in cases with MIS-C.

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