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Cardiovascular Fitness and Cognitive Spatial Learning in Rodents and in Humans.

Authors
  • Barak, Boaz
  • Feldman, Noa
  • Okun, Eitan
Type
Published Article
Journal
The journals of gerontology. Series A, Biological sciences and medical sciences
Publication Date
Sep 01, 2015
Volume
70
Issue
9
Pages
1059–1066
Identifiers
DOI: 10.1093/gerona/glu162
PMID: 25227128
Source
Medline
Keywords
License
Unknown

Abstract

The association between cardiovascular fitness and cognitive functions in both animals and humans is intensely studied. Research in rodents shows that a higher cardiovascular fitness has beneficial effects on hippocampus-dependent spatial abilities, and the underlying mechanisms were largely teased out. Research into the impact of cardiovascular fitness on spatial learning in humans, however, is more limited, and involves mostly behavioral and imaging studies. Herein, we point out the state of the art in the field of spatial learning and cardiovascular fitness. The differences between the methodologies utilized to study spatial learning in humans and rodents are emphasized along with the neuronal basis of these tasks. Critical gaps in the study of spatial learning in the context of cardiovascular fitness between the two species are discussed.

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