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Cardiovascular events in hospitalised patients with schizophrenia: a survival analysis.

Authors
  • Al-Seddik, Ghina1
  • Hachem, Dory2
  • Haddad, Chadia2
  • Hallit, Souheil2, 3, 4
  • Salameh, Pascale5, 4, 6
  • Nabout, Rita1
  • Zoghbi, Marouan2, 7
  • 1 a Faculty of Sciences , Lebanese University , Beirut , Lebanon. , (Lebanon)
  • 2 b Psychiatric Hospital of the Cross , Jal Eddib , Lebanon. , (Lebanon)
  • 3 d Faculty of Medicine and Medical Sciences , Holy Spirit University , Kaslik , Lebanon. , (Lebanon)
  • 4 e INSPECT-LB: Institut National de Sante Publique, Epidemiologie Clinique et Toxicologie , Beirut , Lebanon. , (Lebanon)
  • 5 c Faculty of Pharmacy , Lebanese University , Beirut , Lebanon. , (Lebanon)
  • 6 f Faculty of Medicine , Lebanese University , Beirut , Lebanon. , (Lebanon)
  • 7 g Faculty of Medicine , Saint-Joseph University , Beirut , Lebanon. , (Lebanon)
Type
Published Article
Journal
International journal of psychiatry in clinical practice
Publication Date
Jun 01, 2019
Volume
23
Issue
2
Pages
106–113
Identifiers
DOI: 10.1080/13651501.2018.1545910
PMID: 30741069
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Objective: To evaluate the occurrence of cardiovascular (CV), cerebrovascular events and mortality rates, and compare the predictive ability of two scores, Framingham Risk Score (FRS) and Atherosclerotic Cardiovascular Disease (ASCVD), of detecting a cardiovascular event in a cohort of schizophrenic patients. Methods: A cohort of 329 hospitalised schizophrenic patients is being monitored since 1 January 2013. Patients' file review was performed to detect the CV events of interest. Results: Out of the 329 patients with schizophrenia, with a mean study follow-up of 41.07 ± 12.55 months, 29 cardiovascular events were recorded; of those events, we recorded 4 myocardial infarction, 1 stroke, 6 heart failure and 18 cardiovascular deaths. The major composite outcome of cardiovascular events rate was equal to 9.0 per 100 patient-years. The secondary composite outcome of cardiovascular events rate was equal to 7.2 per 100 patient-years (0.072 events per patient). The association between survival curve of patients with high and low CVR according to FRS score tended to significance (RR = 1.90, p = .078). Patients classified as high cardiovascular risk according to ASCVD presented a reduced cardiovascular survival (RR = 3.35, p = .005). Conclusion: The ASCVD items should be included in the medical assessment in any patient with severe mental illness. Key points The major composite outcome of cardiovascular events rate was equal to 9.0 per 100 patient-years. The secondary composite outcome of cardiovascular events rate was equal to 7.2 per 100 patient-years (0.072 events per patient). The association between survival curve of patients with high and low CVR according to FRS score tended to significance. Patients classified as high cardiovascular risk according to ASCVD presented a reduced cardiovascular survival. The ASCVD items should be included in the medical assessment in any patient with severe mental illness.

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