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Cardiovascular events associated with the use of four nonselective NSAIDs (etodolac, nabumetone, ibuprofen, or naproxen) versus a cyclooxygenase-2 inhibitor (celecoxib): a population-based analysis in Taiwanese adults.

Authors
  • Huang, Weng-Foung
  • Hsiao, Fei-Yuan
  • Wen, Yu-Wen
  • Tsai, Yi-Wen
Type
Published Article
Journal
Clinical Therapeutics
Publisher
Elsevier
Publication Date
Nov 01, 2006
Volume
28
Issue
11
Pages
1827–1836
Identifiers
PMID: 17213003
Source
Medline
License
Unknown

Abstract

In this cohort study of long-term (> or = 180 days) use of NSAIDs in Taiwanese adults, no significant differences in the risk for treatment-related CVEs were observed between groups prescribed 1 of 4 nonselective NSAIDs (etodolac, nabumetone, ibuprofen, or naproxen) or celecoxib. History of CVD was the most significant determinant of CVE risk. Patients with preexisting medical conditions appeared to have a significantly higher risk for CVEs associated with the use of NSAIDs and celecoxib compared with patients without these conditions.

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