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Cardiovascular actions of CRH and urocortin: an update.

Authors
  • Parkes, D G
  • Weisinger, R S
  • May, C N
Type
Published Article
Journal
Peptides
Publisher
Elsevier
Publication Date
May 01, 2001
Volume
22
Issue
5
Pages
821–827
Identifiers
PMID: 11337096
Source
Medline
License
Unknown

Abstract

Urocortin is a potent regulator of cardiac function, with actions that are prolonged in experimental animals. These changes are mediated via binding to CRH receptors found in peripheral tissues. The diversity of actions of urocortin on behaviour, appetite, inflammation and the cardiovascular system suggest that this peptide may be an endogenous factor mediating actions previously attributed to CRH. The present review will focus on the recent understanding of mechanisms mediating the cardiovascular actions of urocortin and CRH reported to date.

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