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Cardiotoxicity due to targeted anticancer agents: a growing challenge.

Authors
  • Shah, Chintan P1
  • Moreb, Jan S2
  • 1 Department of Medicine, Hematology Oncology Division, University of Florida, 1600 SW Archer Road, Gainesville, 32608, FL, USA.
  • 2 Department of Medicine, Hematology Oncology Division, University of Florida, Gainesville, FL, USA.
Type
Published Article
Journal
Therapeutic advances in cardiovascular disease
Publication Date
Jan 01, 2019
Volume
13
Identifiers
DOI: 10.1177/1753944719843435
PMID: 30995890
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The emergence of various targeted anticancer agents has led us to uncharted territory secondary to their cardiotoxic potential with many burning questions, which in turn has led to the evolution of the cardio-oncology field. These targeted agents differ in their cardiovascular complication (CVC) potential even within the same class and it is very difficult to design screening tests that can predict CVCs. Moreover, there is a need for more research to answer many crucial questions, since these toxicities are unanticipated and can lead to poor overall survival of cancer patients. We still do not clearly understand the mechanism for such toxicity, risk factors, and natural history. A better understanding of the underlying risk factors and identification of biomarkers would help us develop protocols for appropriate monitoring strategies which in turn would help capture these toxicities at early stages. In this succinct review, we try to focus on CVC definition, summarize some published research, and point to areas of unmet need in this new field.

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