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Cardiorespiratory effects of exchange transfusions with synthetic erythrocytes in rats.

Authors
  • Djordjevich, L
  • Mayoral, J
  • Miller, I F
  • Ivankovich, A D
Type
Published Article
Journal
Critical Care Medicine
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Apr 01, 1987
Volume
15
Issue
4
Pages
318–323
Identifiers
PMID: 3816278
Source
Medline
License
Unknown

Abstract

Synthetic erythrocytes (SE) can maintain life with near-normal hemodynamics in rats with hematocrits (Hct) 45% below the lethal levels, as shown when we exchanged virtually all their blood. We compared cardiorespiratory variables between the SE and control animals, which were hemodiluted with 7% albumin, at the 78% exchange level. In addition, SE animals at 92% exchange were compared with the 78% exchange and baseline levels. All our control rats died at Hct above 5% with corresponding oxygen-carrying capacity of 2.65 ml/dl. All SE rats survived, having a final Hct of 2.96% with an oxygen-carrying capacity of 7.05 ml/dl. SE animals maintained normal BP and marginally increased cardiac output, while control animals did not. Vascular resistance of control animals at 78% exchange was reduced to 30%, while in SE animals at 92% exchange, vascular resistance was lowered to 80% of baseline values.

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