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Cardioprotective Effect of the Adaptive Phenomenon of Early Hypoxic Preconditioning and Its Pharmacological Imitation

Authors
  • Sementsov, A. S.1, 2
  • Maslov, L. N.1
  • Bushov, Yu. V.2
  • 1 Research Institute of Cardiology, Tomsk National Medical Research Center, Russian Academy of Sciences, Tomsk, Russia , Tomsk (Russia)
  • 2 National Research Tomsk State University, Tomsk, Russia , Tomsk (Russia)
Type
Published Article
Journal
Neuroscience and Behavioral Physiology
Publisher
Springer US
Publication Date
Apr 26, 2019
Volume
49
Issue
4
Pages
468–473
Identifiers
DOI: 10.1007/s11055-019-00757-5
Source
Springer Nature
Keywords
License
Yellow

Abstract

The roles of NO synthase and ATP-dependent K+ channels (KATP channels) in the development of the infarct-limiting effect of early hypoxic preconditioning (HP) in rats were studied and the potential for pharmacological simulation of this phenomenon was demonstrated. HP was modeled by alternation of six 10-min sessions of normobaric hypoxia (8% O2) and six 10-min periods of reoxygenation with atmospheric oxygen (21% O2). The total duration of the adaptive action was 120 min. These results indicate that NO synthase and KATP channels play the role of mediators in the signal mechanism of HP. NO donors and KATP channel activators allow the protective effect of hypoxic preconditioning to be reproduced by administration 1 h before ischemia/reperfusion but not when given 2 h 30 min before coronary occlusion.

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