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Cardioplegic protection with hypothermic K-Fluosol DA and K/Mg-Fluosol DA solutions.

Authors
  • Kyösola, K
  • Harjula, A
  • Mattila, S
  • Aalto-Setälä, K
  • Mattila, I
  • Mattila, P
  • Salmenperä, M
  • Merikallio, E
Type
Published Article
Journal
Scandinavian journal of thoracic and cardiovascular surgery
Publication Date
Jan 01, 1985
Volume
19
Issue
3
Pages
267–272
Identifiers
PMID: 4081676
Source
Medline
License
Unknown

Abstract

Oxygenated fluorocarbon cardioplegic solution was tested in 20 isolated rabbit hearts. In 10 of the hearts, 150 ml of solution (Fluosol DA) with addition of 20 mmol/l potassium, 4 degrees C, was infused during 3 min into the aortic root (infusion pressure 60-80 mmHg). The other 10 hearts were perfused with Fluosol DA containing 20 mmol/l potassium and 15 mmol/l magnesium. The hearts were left immersed in the perfusion solution for 2 hours. Myocardial biopsies were performed while the hearts were still beating, immediately after completion of the cardioplegic infusion and 60 and 120 min later. Transmission electron microscopy showed progressive, time-related deterioration of the myocardial cells, characteristic of myocardial ischaemia, in both groups. The changes, however, were clearly less pronounced in the K/Mg-Fluosol DA group. Myocardial capillaries remained patent in both groups throughout the observation period, but the capillary endothelium was better preserved in the K/Mg-Fluosol DA group. The study thus indicated that K/Mg-Fluosol DA was superior to K-Fluosol DA as a cardioplegic agent in terms of ultrastructural preservation of the myocardial cells and the endothelial lining of the myocardial capillaries.

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