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Cardiomyocyte specific peroxisome proliferator-activated receptor-α overexpression leads to irreversible damage in ischemic murine heart.

Authors
  • Duerr, Georg D1
  • Heinemann, Jan C2
  • Arnoldi, Vanessa2
  • Feisst, Andreas2
  • Kley, Julian2
  • Ghanem, Alexander3
  • Welz, Armin2
  • Dewald, Oliver2
  • 1 Department of Cardiac Surgery, University Clinical Center Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. Electronic address: [email protected] , (Germany)
  • 2 Department of Cardiac Surgery, University Clinical Center Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. , (Germany)
  • 3 Department of Cardiology, Pneomology and Angiology - Medizinische Klinik II, University Clinical Center Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany. , (Germany)
Type
Published Article
Journal
Life sciences
Publication Date
May 02, 2014
Volume
102
Issue
2
Pages
88–97
Identifiers
DOI: 10.1016/j.lfs.2014.03.019
PMID: 24657893
Source
Medline
Keywords
License
Unknown

Abstract

Cardiomyocyte-specific PPAR-α overexpression led to irreversible cardiomyocyte loss with deteriorated ventricular function during brief, repetitive I/R episodes. We identified higher glycogen deposition, increased apoptosis, deranged antioxidative capacity and maladaptation of contractile elements as major contributors involved in the modulation of post-ischemic inflammation and remodeling.

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