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Cardiolipin and the Nlrp3 inflammasome.

Authors
  • O'Neill, Luke A J1
  • 1 School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: [email protected] , (Ireland)
Type
Published Article
Journal
Cell metabolism
Publication Date
Nov 05, 2013
Volume
18
Issue
5
Pages
610–612
Identifiers
DOI: 10.1016/j.cmet.2013.10.013
PMID: 24206659
Source
Medline
License
Unknown

Abstract

The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting inflammation.

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