Affordable Access

Cardiac-Referenced Leukocyte Telomere Length and Outcomes After Cardiovascular Surgery

Authors
  • Yin, Hao
  • Akawi, Oula
  • Fox, Stephanie A.
  • Li, Fuyan
  • O'Neil, Caroline
  • Balint, Brittany
  • Arpino, John-Michael
  • Watson, Alanna
  • Wong, Jorge
  • Guo, Linrui
  • Quantz, MacKenzie A.
  • Nagpal, A. Dave
  • Kiaii, Bob
  • Chu, Michael W.A.
  • Pickering, J. Geoffrey
Publication Date
Nov 12, 2018
Source
PubMed Central
Keywords
Language
English
License
Unknown
External links

Abstract

Leukocyte telomere shortening reflects stress burdens and has been associated with cardiac events. However, the patient-specific clinical value of telomere assessment remains unknown. Moreover, telomere shortening cannot be inferred from a single telomere length assessment. The authors investigated and developed a novel strategy for gauging leukocyte telomere shortening using autologous cardiac atrial referencing. Using multitissue assessments from 163 patients who underwent cardiovascular surgery, we determined that the cardiac atrium-leukocyte telomere length difference predicted post-operative complexity. This constituted the first evidence that a single-time assessment of telomere dynamics might be salient to acute cardiac care.

Report this publication

Statistics

Seen <100 times