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Cardiac regeneration in the axolotl is unaffected by alterations in leukocyte numbers induced by lipopolysaccharide and prednisolone

Authors
  • Pedersen, Kathrine1
  • Rasmussen, Rikke Kongsgaard1
  • Dittrich, Anita1
  • Lauridsen, Henrik1
  • 1 Aarhus University, Aarhus N, 8200, Denmark , Aarhus N (Denmark)
Type
Published Article
Journal
BMC Research Notes
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Apr 28, 2021
Volume
14
Issue
1
Identifiers
DOI: 10.1186/s13104-021-05574-z
Source
Springer Nature
Keywords
License
Green

Abstract

ObjectiveCardiac regeneration in the axolotl has been found to rely on the innate immune system, and especially macrophages have been demonstrated to play a vital role in regulating the regenerative process. In this study we wanted to induce a pro- and anti-inflammatory milieu in the axolotl during heart regeneration to test the resilience of the regenerative response.ResultsThis was induced via repeated intrapericardial injections of lipopolysaccharide or prednisolone during a 40-day regeneration period in order to challenge the presumably fine-tuned inflammatory response that normally facilitates regeneration. We observed a local and systemic leucocyte response to pro- and anti-inflammatory stimulation, but we found cardiac regeneration to be structurally and functionally unaffected.

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