Affordable Access

Access to the full text

Cardiac Pacemaker Activity and Aging

Authors
  • Peters, Colin H.
  • Sharpe, Emily J.
  • Proenza, Catherine
Type
Published Article
Journal
Annual Review of Physiology
Publisher
Annual Reviews
Publication Date
Feb 10, 2020
Volume
82
Pages
21–43
Identifiers
DOI: 10.1146/annurev-physiol-021119-034453
Source
Annual Reviews
Keywords
License
Yellow

Abstract

A progressive decline in maximum heart rate (mHR) is a fundamental aspect of aging in humans and other mammals. This decrease in mHR is independent of gender, fitness, and lifestyle, affecting in equal measure women and men, athletes and couch potatoes, spinach eaters and fast food enthusiasts. Importantly, the decline in mHR is the major determinant of the age-dependent decline in aerobic capacity that ultimately limits functional independence for many older individuals. The gradual reduction in mHR with age reflects a slowing of the intrinsic pacemaker activity of the sinoatrial node of the heart, which results from electrical remodeling of individual pacemaker cells along with structural remodeling and a blunted β-adrenergic response. In this review, we summarize current evidence about the tissue, cellular, and molecular mechanisms that underlie the reduction in pacemaker activity with age and highlight key areas for future work.

Report this publication

Statistics

Seen <100 times