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Cardiac Extracellular Matrix Modification as a Therapeutic Approach.

Authors
  • Hall, Mikayla L1, 2
  • Ogle, Brenda M3, 4, 5, 6, 7
  • 1 Department of Biomedical Engineering, University of Minnesota - Twin Cities, Minneapolis, MN, USA.
  • 2 Stem Cell Institute, University of Minnesota - Twin Cities, Minneapolis, MN, USA.
  • 3 Department of Biomedical Engineering, University of Minnesota - Twin Cities, Minneapolis, MN, USA. [email protected]
  • 4 Stem Cell Institute, University of Minnesota - Twin Cities, Minneapolis, MN, USA. [email protected]
  • 5 Masonic Cancer Center, University of Minnesota - Twin Cities, Minneapolis, MN, USA. [email protected]
  • 6 Lillehei Heart Institute, University of Minnesota - Twin Cities, Minneapolis, MN, USA. [email protected]
  • 7 Institute for Engineering in Medicine, University of Minnesota - Twin Cities, Minneapolis, MN, USA. [email protected]
Type
Published Article
Journal
Advances in experimental medicine and biology
Publication Date
Jan 01, 2018
Volume
1098
Pages
131–150
Identifiers
DOI: 10.1007/978-3-319-97421-7_7
PMID: 30238369
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The cardiac extracellular matrix (cECM) is comprised of proteins and polysaccharides secreted by cardiac cell types, which provide structural and biochemical support to cardiovascular tissue. The roles of cECM proteins and the associated family of cell surface receptor, integrins, have been explored in vivo via the generation of knockout experimental animal models. However, the complexity of tissues makes it difficult to isolate the effects of individual cECM proteins on a particular cell process or disease state. The desire to further dissect the role of cECM has led to the development of a variety of in vitro model systems, which are now being used not only for basic studies but also for testing drug efficacy and toxicity and for generating therapeutic scaffolds. These systems began with 2D coatings of cECM derived from tissue and have developed to include recombinant ECM proteins, ECM fragments, and ECM mimics. Most recently 3D model systems have emerged, made possible by several developing technologies including, and most notably, 3D bioprinting. This chapter will attempt to track the evolution of our understanding of the relationship between cECM and cell behavior from in vivo model to in vitro control systems. We end the chapter with a summary of how basic studies such as these have informed the use of cECM as a direct therapy.

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