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Carcinosarcoma of the ovary: MR and clinical findings compared with high-grade serous carcinoma

Authors
  • Saida, Tsukasa1
  • Mori, Kensaku1
  • Tanaka, Yumiko Oishi2
  • Sakai, Masafumi1
  • Amano, Taishi1
  • Kikuchi, Shunsuke1
  • Masuoka, Souta1
  • Yoshida, Miki1
  • Masumoto, Tomohiko1
  • Satoh, Toyomi1
  • Minami, Manabu1
  • 1 University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan , Tsukuba (Japan)
  • 2 The Cancer Institute Hospital Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto, Tokyo, 135-8550, Japan , Ariake, Koto, Tokyo (Japan)
Type
Published Article
Journal
Japanese Journal of Radiology
Publisher
Springer Singapore
Publication Date
Nov 20, 2020
Volume
39
Issue
4
Pages
357–366
Identifiers
DOI: 10.1007/s11604-020-01072-7
Source
Springer Nature
Keywords
License
Yellow

Abstract

PurposeTo clarify imaging and clinical characteristics of ovarian carcinosarcoma (CS) compared with high-grade serous carcinoma (HGSC).MethodsWe retrospectively reviewed MR imagings of 12 patients with CS and 30 patients with HGSC and evaluated tumor size, shape, appearance, nature of cystic and solid components, hemorrhage, and necrosis. Age, premenopausal or postmenopausal, histologic subtype, presence of endometriosis, tumor markers, and stage were also evaluated. These parameters were compared using the Mann–Whitney U test and the chi-square test/Fisher’s exact test.ResultsThe mean size of CSs was 13.6 cm, and significantly larger than that of HGSCs (mean 9.0 cm, p = 0.022). The stained-glass appearance (67% vs. 23%, p = 0.013), hemorrhage (100% vs. 50%, p = 0.003), necrosis (75.0% vs. 13%, p = 0.000), and endometriosis (33% vs. 7%, p = 0.012) were significantly more common in CSs. The postmenopausal ratio of CSs was 100% and significantly higher than that of HGSCs (70.0%, p = 0.041). Among the tumor makers, only CA-125 was significantly lower in CSs than in HGSCs (mean 715.1 U/ml vs. 1677.1 U/ml, p = 0.009). The stage distribution was similar and was not significantly different.ConclusionCSs formed larger masses, and the stained-glass appearance, hemorrhage, and necrosis were more frequently observed in CSs.

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