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Carcinogenicity of dimethylnitramine in NZR rats in NZO mice.

Authors
  • Goodall, C M
  • Kennedy, T H
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
May 01, 1976
Volume
1
Issue
5
Pages
295–298
Identifiers
PMID: 189904
Source
Medline
Language
English
License
Unknown

Abstract

Lifetime tests were done in NZR inbred rats of dimethylnitramine (DMNO) by addition to the drinking water (average dose 1.83 g/kg body weight) and in NZO mice by repeated subcutaneous injection from birth to 7 months of age followed by administration in drinking water (total average dose 4.72 g/kg body weight). Rats developed hepatocellular carcinomas (85%), some of which metastasized. Mice developed hepatocellular carcinomas (81%) and renal adenocarcinomas (48%). Statistically significant increases of other tumor types also occurred in mice. The main targets for DMNO carcinogenesis appeared to be the liver cell epithelium and, at higher dose rates, renal tubular epithelium.

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