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Carcinogenicity of 4-hydroxybutyl-butylnitrosamine in Syrian hamsters.

Authors
  • Althoff, J
  • Krüger, F W
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Sep 01, 1975
Volume
1
Issue
1
Pages
15–19
Identifiers
PMID: 1235053
Source
Medline
License
Unknown

Abstract

4-Hydroxybutyl-butylnitrosamine (HBBN), a urinary metabolite of dibutylnitrosamine (DBN) was shown to induce respiratory and bile duct tumors as well as carcinomas of the urinary bladder in Syrian golden hamsters. This contrasts with results previously obtained in rats and demonstrates that HBBN is not a specific bladder carcinogen. Bronchogenic tumors, seen in DBN-treated hamsters, were not observed after injection of HBBN.

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