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The carcinogenic effect of dimethylnitrosamine on the Chinese hamster (Cricetulus griseus).

Authors
  • Reznik, G
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Sep 01, 1975
Volume
1
Issue
1
Pages
25–28
Identifiers
PMID: 1235055
Source
Medline
License
Unknown

Abstract

Three groups of Chinese hamsters (20 males, 20 females/group) received weekly subcutaneous injections for life of dimethylnitrosamine (DMN) at dose levels 0.20, 0.10 and 0.05 of the LD50. Eighty-two to 100% of the animals developed tumors of vascular origin. The neoplasms were primarily hepatic hemangioendotheliomas and their incidence was unrelated to dose or sex. Although animals in the low dose group received a total dose which was one-third that of the highest dose group, their survival times were only slightly longer.

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