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[Carcinoembryonal antigen and the follow up of patients after resection of colon carcinoma with curative intent: a Markov process in decision analysis].

Authors
  • Kievit, J
  • van de Velde, C J
  • de Vries, B C
Type
Published Article
Journal
Nederlands tijdschrift voor geneeskunde
Publication Date
Sep 09, 1989
Volume
133
Issue
36
Pages
1784–1789
Identifiers
PMID: 2812076
Source
Medline
License
Unknown

Abstract

The follow-up of colon cancer patients by monitoring serum carcinoembryonic antigen has advantages (better survival after early detection of recurrence by CEA rise) as well as disadvantages (false-positive rise of CEA, and early detection of incurable recurrences in asymptomatic patients). The effects of CEA follow-up on quality-adjusted life expectancy (QUALE) of patients with curatively resected colon carcinoma have been simulated by a Markov analysis using literature data. The value of CEA seems insignificant and varies, depending on the literature data used, from a mean increase of QUALE by 6 days (+0.4%) to a mean decrease by 2 days (-0.07%). This value depends on patient-related variables; the negative effects of CEA especially predominate in older patients with favourable Dukes' stages of primary tumour.

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