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A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2

Authors
  • Liu, Yo-Min1, 2
  • Shahed-Al-Mahmud, Md.1
  • Chen, Xiaorui1
  • Chen, Ting-Hua1
  • Liao, Kuo-Shiang1
  • Lo, Jennifer M.1
  • Wu, Yi-Min3
  • Ho, Meng-Chiao3
  • Wu, Chung-Yi1
  • Wong, Chi-Huey1
  • Jan, Jia-Tsrong1
  • Ma, Che1
  • 1 Genomics Research Center, Academia Sinica, Taipei 115, Taiwan
  • 2 Institute of Microbiology and Immunology, National Yang Ming University, Taipei 112, Taiwan
  • 3 Institute of Biological Chemistry and Cryo-EM Center, Academia Sinica, Taipei 115, Taiwan
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Jul 24, 2020
Volume
32
Issue
6
Pages
108016–108016
Identifiers
DOI: 10.1016/j.celrep.2020.108016
PMID: 32755598
PMCID: PMC7380208
Source
PubMed Central
Keywords
License
Unknown

Abstract

Liu et al. demonstrate that FRIL, a plant lectin isolated from the hyacinth bean, has potent antiviral activity against SARS-CoV-2 and diverse influenza virus strains. FRIL is effective in vivo against H1N1. FRIL’s antiviral activity is mediated by binding to complex-type N-glycans on viral glycoproteins, interfering with viral entry.

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