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Carbohydrate-actuated nanofluidic diode: switchable current rectification in a nanopipette.

Authors
  • Vilozny, Boaz
  • Wollenberg, Alexander L
  • Actis, Paolo
  • Hwang, Daniel
  • Singaram, Bakthan
  • Pourmand, Nader
Type
Published Article
Journal
Nanoscale
Publisher
The Royal Society of Chemistry
Publication Date
Oct 07, 2013
Volume
5
Issue
19
Pages
9214–9221
Identifiers
DOI: 10.1039/c3nr02105j
PMID: 23934399
Source
Medline
License
Unknown

Abstract

Nanofluidic structures share many properties with ligand-gated ion channels. However, actuating ion conductance in artificial systems is a challenge. We have designed a system that uses a carbohydrate-responsive polymer to modulate ion conductance in a quartz nanopipette. The cationic polymer, a poly(vinylpyridine) quaternized with benzylboronic acid groups, undergoes a transition from swollen to collapsed upon binding to monosaccharides. As a result, the current rectification in nanopipettes can be reversibly switched depending on the concentration of monosaccharides. Such molecular actuation of nanofluidic conductance may be used in novel sensors and drug delivery systems.

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