Affordable Access

Carbocyclic analogs of arabinosylpurine nucleosides.

Authors
  • Lee, H
  • Vince, R
Type
Published Article
Journal
Journal of pharmaceutical sciences
Publication Date
Sep 01, 1980
Volume
69
Issue
9
Pages
1019–1021
Identifiers
PMID: 6251197
Source
Medline
License
Unknown

Abstract

Carbocyclic analogs of arabinofuranosylguanine (VII) and 2,6-diamino-9-beta-arabinofuranosylpurine (VIII) and the corresponding 8-azapurine analogs, 5-amino-7-hydroxy-3-[2 alpha,3 beta-dihydroxy-4 alpha-(hydroxymethyl)cyclopent-1 alpha-yl]-v-triazolo[4,5-d]pyrimidine (X) and 5,7-diamino-3-[2 alpha,3 beta-dihydroxy-4 alpha-(hydroxymethyl)cyclopent-1 alpha-yl]-v-triazolo[4,5-d]pyrimidine (XI), were prepared. Carbocyclic nucleoside analogs VII and X exhibited significant cytotoxicity against P-388 mouse leukemia cells in culture. In vitro testing against herpes simplex type 1 (strain HF) indicated that only VIII exhibited significant antiviral activity.

Report this publication

Statistics

Seen <100 times