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Carbamate prodrugs of N-alkylfuramidines.

Authors
  • Rahmathullah, Syed M
  • Tidwell, Richard R
  • Jones, Susan K
  • Hall, James E
  • Boykin, David W
Type
Published Article
Journal
European Journal of Medicinal Chemistry
Publisher
Elsevier
Publication Date
Jan 01, 2008
Volume
43
Issue
1
Pages
174–177
Identifiers
PMID: 17499888
Source
Medline
License
Unknown

Abstract

The synthesis and evaluation of 2,5-bis[4-(N-ethoxycarbonyl-N'-isopropyl)amidinophenyl]furan, 2,5-bis[4-(N-2,2,2-trichloroethoxycarbonyl-N'-isopropyl)amidinophenyl]furan and 2,5-bis[4-(N-cyclopentyl-N'-2,2,2-trichloroethoxycarbonyl)amidinophenyl]furan as prodrugs of bis-N-alkylamidines are reported. The results show that the bis-2,2,2-trichloroethyl carbamates function effectively in a rat model for Pneumocystis pneumonia.

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