Affordable Access

Access to the full text

Captain GBP1: inflammasomes assemble, pyroptotic endgame

Authors
  • Feng, Shouya1
  • Man, Si Ming1
  • 1 The Australian National University, Canberra, ACT, Australia , Canberra (Australia)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Jul 22, 2020
Volume
21
Issue
8
Pages
829–830
Identifiers
DOI: 10.1038/s41590-020-0727-0
Source
Springer Nature
License
Yellow

Abstract

Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the surface of bacteria to induce pyroptosis.

Report this publication

Statistics

Seen <100 times