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Capsaicin blocks one class of K+ channels in the frog node of Ranvier.

Authors
  • Dubois, J M
Type
Published Article
Journal
Brain Research
Publisher
Elsevier
Publication Date
Aug 12, 1982
Volume
245
Issue
2
Pages
372–375
Identifiers
PMID: 6289968
Source
Medline
License
Unknown

Abstract

Capsaicin (10-20 microM) blocks reversibly one component of the K+ current (IKf2) in frog node of Ranvier. The block is enhanced with depolarization but it is not voltage-dependent indicating that the affinity of receptor sites for capsaicin is larger with the channels in the open configuration. The results provide pharmacological evidence of the existence within the nodal membrane of two classes of fast K+ channels, in addition to the slow K+ channels.

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