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Capillary electrophoretic analysis of ethylene dicysteine, a precursor of the radiopharmaceutical 99mTc ethylene dicysteine.

Authors
  • Van Schepdael, A
  • Verbeke, K
  • Van Nerom, C
  • Hoogmartens, J
  • Verbruggen, A
Type
Published Article
Journal
Journal of chromatography. B, Biomedical sciences and applications
Publication Date
Sep 12, 1997
Volume
697
Issue
1-2
Pages
251–254
Identifiers
PMID: 9342676
Source
Medline
License
Unknown

Abstract

L,L-Ethylene dicysteine (EC) is a ligand used in nuclear medicine for the preparation of 99mTc-L,L-EC, a tracer agent for renal function studies. A capillary zone electrophoretic method is described which allows us to monitor the purity of ethylene dicysteine, for which no other suitable method has been reported to date. A fused-silica capillary (L = 70 cm, l = 62 cm, 75 microns i.d.) was used with 10 mM sodium tetraborate, pH 10.0, as the background electrolyte. The voltage applied was 20 kV and the temperature was 25 degrees C. Benzyl alcohol served as the internal standard. The limit of detection was 0.07% and the limit of quantitation was 0.15%.

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