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Cannabidiol Oil-Associated Microscopic Colitis

Authors
  • Oruganti, Poornima1
  • Betcher, Stephanie1
  • Wakade, Zuie2
  • Ding, Xianzhong3
  • Abegunde, Ayokunle T2
  • 1 Internal Medicine, Loyola University Medical Center, Maywood, USA
  • 2 Gastroenterology, Loyola University Medical Center, Maywood, USA
  • 3 Pathology, Loyola University Medical Center, Maywood, USA
Type
Published Article
Journal
Cureus
Publisher
Cureus
Publication Date
Sep 18, 2020
Volume
12
Issue
9
Identifiers
DOI: 10.7759/cureus.10528
PMID: 33094069
PMCID: PMC7574987
Source
PubMed Central
Keywords
License
Green
External links

Abstract

Microscopic colitis (MC) is a chronic inflammation condition of the colon characterized by watery diarrhea and normal appearing mucosa. A 75-year-old female presented with one-year history of chronic diarrhea while taking cannabidiol (CBD) for pain. Colonoscopy with random colon biopsies revealed collagenous colitis. She started budesonide and stopped CBD. At six-week follow-up, her diarrhea improved, and the budesonide dose was decreased. She restarted CBD oil twice but had diarrhea both times. Her diarrhea resolved after taking budesonide and stopping CBD. We report a case of CBD-associated MC to make clinicians aware of this potential adverse effect in patients who chronically use CBD.

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