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Candida Albicans: a molecular revolution built on lessons from budding yeast.

Authors
  • Berman, Judith
  • Sudbery, Peter E
Type
Published Article
Journal
Nature reviews. Genetics
Publication Date
Dec 01, 2002
Volume
3
Issue
12
Pages
918–930
Identifiers
PMID: 12459722
Source
Medline
License
Unknown

Abstract

Candida albicans is an opportunistic fungal pathogen that is found in the normal gastrointestinal flora of most healthy humans. However, in immunocompromised patients, blood-stream infections often cause death, despite the use of anti-fungal therapies. The recent completion of the C. albicans genome sequence, the availability of whole-genome microarrays and the development of tools for rapid molecular-genetic manipulations of the C. albicans genome are generating an explosion of information about the intriguing biology of this pathogen and about its mechanisms of virulence. They also reveal the extent of similarities and differences between C. albicans and its benign relative, Saccharomyces cerevisiae.

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