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Cancer screening via infrared spectral cytopathology (SCP): results for the upper respiratory and digestive tracts.

Authors
  • Diem, Max1
  • Miljković, Miloš2
  • Bird, Benjamin2
  • Mazur, Antonella I2
  • Schubert, Jen M2
  • Townsend, Douglas2
  • Laver, Nora3
  • Almond, Max4
  • Old, Oliver4
  • 1 Laboratory for Spectral Diagnosis (LSpD), Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA and Cireca Theranostics, LLC, 19 Blackstone St, Cambridge, MA 02139, USA. [email protected]
  • 2 Laboratory for Spectral Diagnosis (LSpD), Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
  • 3 Department of Pathology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA.
  • 4 Biophotonics Research Unit, Gloucestershire Hospitals NHS Foundation Trust, Great Western Road, Gloucester, UK.
Type
Published Article
Journal
The Analyst
Publisher
The Royal Society of Chemistry
Publication Date
Jan 21, 2016
Volume
141
Issue
2
Pages
416–428
Identifiers
DOI: 10.1039/c5an01751c
PMID: 26421636
Source
Medline
License
Unknown

Abstract

Instrumental advances in infrared micro-spectroscopy have made possible the observation of individual human cells and even subcellular structures. The observed spectra represent a snapshot of the biochemical composition of a cell; this composition varies subtly but reproducibly with cellular effects such as progression through the cell cycle, cell maturation and differentiation, and disease. The aim of this summary is to provide a synopsis of the progress achieved in infrared spectral cytopathology (SCP) - the combination of infrared micro-spectroscopy and multivariate methods of analysis - for the detection of abnormalities in exfoliated human cells of the upper respiratory and digestive tract, namely the oral and nasopharyngeal cavities, and the esophagus.

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