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Cancer risk with topical pimecrolimus and tacrolimus.

Type
Published Article
Journal
Prescrire international
Publication Date
Dec 01, 2005
Volume
14
Issue
80
Pages
223–223
Identifiers
PMID: 16400745
Source
Medline
License
Unknown

Abstract

(1) Disturbing reports of cancers linked to topical application of tacrolimus or pimecrolimus have been published. Some involved children. Animal studies had already shown a dose-dependent increase in the incidence of lymphoma in mice and monkeys. (2) In practice, it is better to avoid topical application of these immunosuppressants, which have a negative risk-benefit balance.

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