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Cancer increases risk of in-hospital death from COVID-19 in persons <65 years and those not in complete remission

Authors
  • Li, Qiubai1
  • Chen, Lei1
  • Li, Qin1
  • He, Wenjuan1
  • Yu, Jianming1
  • Chen, Li1
  • Cao, Yulin1
  • Chen, Wenlan1
  • Di Wu,1
  • Dong, Fang2
  • Cai, Liling1
  • Ran, Qijie3
  • Li, Lei4
  • Liu, Qiaomei2
  • Ren, Wenxiang1
  • Gao, Fei1
  • Wang, Hongxiang1
  • Chen, Zhichao1
  • Gale, Robert Peter5
  • Hu, Yu1
  • 1 Huazhong University of Science and Technology,
  • 2 Tongren Hospital of Wuhan University,
  • 3 Department of Hematology, General Hospital of Central Theater Command, PLA, Wuhan, 300700 China
  • 4 Wuhan Jin-Yin-Tan Hospital, Wuhan, China
  • 5 Imperial College London,
Type
Published Article
Journal
Leukemia
Publisher
Springer Nature
Publication Date
Jul 20, 2020
Pages
1–8
Identifiers
DOI: 10.1038/s41375-020-0986-7
PMID: 32690880
PMCID: PMC7371786
Source
PubMed Central
Keywords
License
Unknown

Abstract

The impact of cancer on outcome of persons with coronavirus disease 2019 (COVID-19) after infection with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is controversial. We studied 1859 subjects with COVID-19 from seven centers in Wuhan, China, 65 of whom had cancer. We found having cancer was an independent risk factor for in-hospital death from COVID-19 in persons <65 years (hazard ratio [HR] = 2.45, 95% confidence interval [CI], 1.04, 5.76; P = 0.041) but not in those ≥65 years (HR = 1.12 [0.56, 2.24]; P = 0.740). It was also more common in those not in complete remission. Risks of in-hospital death were similar in subjects with solid cancers and those with hematological cancers. These data may help predict outcomes of persons with cancer and COVID-19.

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