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Cancer Epigenetics for the 21st Century: What's Next?

Authors
  • Esteller, Manel1
  • 1 Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet, Barcelona, Catalonia, Spain. , (Spain)
Type
Published Article
Journal
Genes & Cancer
Publisher
"Impact Journals, LLC "
Publication Date
Jun 01, 2011
Volume
2
Issue
6
Pages
604–606
Identifiers
DOI: 10.1177/1947601911423096
PMID: 21941616
Source
Medline
Keywords
License
Unknown

Abstract

The discovery of global DNA hypomethylation events in human tumors in the early 1980s and the identification of CpG island promoter hypermethylation of tumor suppressor genes in cancer cells in the mid 1990s opened the door to the current excitement about the contribution of epigenetic disruption to human disease. The recent gigantic advances in technology make it possible to obtain complete DNA methylomes, histonomes, and non-coding RNA transcriptomes for many biological settings and their associated disorders. Furthermore, whole genome sequencing analyses yields an increasing number of mutated epigenetic genes in neoplasia. It is time to sit back, enjoy the show with a little help of friendly bioinformatic tools, and wonder about what will happen next.

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