Cancer after pre-eclampsia: follow up of the Jerusalem perinatal study cohort

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Cancer after pre-eclampsia: follow up of the Jerusalem perinatal study cohort

Publisher
BMJ Publishing Group Ltd.
Publication Date
Apr 17, 2004
Source
PMC
Keywords
Disciplines
  • Biology
  • Ecology
  • Geography
License
Unknown

Abstract

Cancer after pre-eclampsia: follow up of the Jerusalem perinatal study cohort Ora Paltiel, Yehiel Friedlander, Efrat Tiram, Micha Barchana, Xiaonan Xue, Susan Harlap Abstract Objective To compare the incidence of cancer among women with and without a history of pre-eclampsia. Design Cohort study. Setting Jerusalem perinatal study of women who delivered in three large hospitals in West Jerusalem during 1964-76. Participants 37 033 women. Main outcome measures Age adjusted and multivariable adjusted hazard ratios for cancer incidence for the entire cohort and for women who were primiparous at study entry. Results Cancer developed in 91 women who had pre-eclampsia and 2204 who did not (hazard ratio 1.27, 95% confidence interval 1.03 to 1.57). The risk of site specific cancers was increased, particularly of the stomach, ovary epithelium, breast, and lung or larynx. The incidence of cancer of the stomach, breast, ovary, kidney, and lung or larynx was increased in primiparous women at study entry who had a history of pre-eclampsia. Conclusions A history of pre-eclampsia is associated with increases in overall risk of cancer and incidence at several sites. This may be explained by environmental and genetic factors common to the development of pre-eclampsia and cancer in this population. Introduction Previous cohort and case-control studies have shown an inconsistent association between risk of cancer and risk of death from cancer in women who have or have not had pre-eclampsia (see bmj.com). Several studies have found that maternal pre-eclampsia reduces the risk of breast cancer up to fourfold in female offspring.1 We investigated overall cancer incidence as well as incidence at specific sites in women in the Jerusalem perinatal study cohort who had or had not had pre-eclampsia. Methods The Jerusalem perinatal study cohort comprises all births in 1964-76 to residents of West Jerusalem. It was intended as a survey of pre-eclampsia, defined as a systolic blood pressure of ≥ 140 mm Hg or a diastol

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