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[CaN-NFAT3 signal pathway: a crucial hinge relates Ca2+ signal with cardiomyocyte hypertrophy].

Authors
  • Zhu, Shan-jun
  • Yang, Yong-jian
  • Yu, Lin-jun
  • Huang, Lan
Type
Published Article
Journal
Zhonghua nei ke za zhi
Publication Date
Jan 01, 2004
Volume
43
Issue
1
Pages
19–21
Identifiers
PMID: 14990015
Source
Medline
License
Unknown

Abstract

It is shown that both Ca2+ inflow and release may activate CaN-NFAT3 signal pathway, which responds to increase of [Ca2+]i and is independent of its origin, indicating the augment of [Ca2+]i may trigger CaN-NFAT3 signal transduction and consequently induce myocyte hypertrophy. Moreover, CsA may restrain the expression and activation of CaN-NFAT3 and protein synthesis of myocytes in response to Ang II and RY stimulation.

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