[CaN-NFAT3 signal pathway: a crucial hinge relates Ca2+ signal with cardiomyocyte hypertrophy].
- Published Article
Zhonghua nei ke za zhi
- Publication Date
Jan 01, 2004
It is shown that both Ca2+ inflow and release may activate CaN-NFAT3 signal pathway, which responds to increase of [Ca2+]i and is independent of its origin, indicating the augment of [Ca2+]i may trigger CaN-NFAT3 signal transduction and consequently induce myocyte hypertrophy. Moreover, CsA may restrain the expression and activation of CaN-NFAT3 and protein synthesis of myocytes in response to Ang II and RY stimulation.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/14990015