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Can coffee or chewing gum decrease transit times in Colon capsule endoscopy? A randomized controlled trial

  • Buijs, Maria Magdalena1, 2
  • Kobaek-Larsen, Morten1
  • Kaalby, Lasse1
  • Baatrup, Gunnar1, 2
  • 1 University of Southern Denmark, Department of Clinical Research, Winsløwsparken 19, 3rd floor, Odense, 5000, Denmark , Odense (Denmark)
  • 2 Odense University Hospital, Department of Surgery, Baagøes Allé 15, Forskningshus, Svendborg, 5700, Denmark , Svendborg (Denmark)
Published Article
BMC Gastroenterology
Springer (Biomed Central Ltd.)
Publication Date
Jun 25, 2018
DOI: 10.1186/s12876-018-0824-9
Springer Nature


BackgroundA high rate of complete colon capsule endoscopy (CCE) investigations is required for a more widespread use of CCE. The objective of this study was to assess if coffee or chewing gum can increase excretion of the colon capsule within battery life time (excretion rate).MethodsOne hundred eighty six screening participants with a positive immunochemical fecal occult blood test were included in this single-centre randomized controlled trial with blinding of the investigators to the randomization. Participants received instant coffee, chewing gum or nothing in addition to the standard bowel preparation.ResultsThe intention was to include 57 participants in the coffee group, 61 in the chewing gum group and 60 in the control group, on 8 participants data were missing. A total of 165 participants were included in a per protocol analysis. Exclusion was due to not receiving the allocated intervention (8 coffee, 4 chewing gum) and technical failure of the capsule (1 coffee). The excretion rate was 58% in the coffee group (n = 48), 63% in the chewing gum group (n = 57) and 55% in the control group (n = 60, p > 0.2). Transit times were similar in all groups. The excretion rate was low in participants who had transit times over 10 h (14%). A strong correlation was found between adequate cleansing and excretion of the capsule.There were no serious adverse events related to the interventions or CCE investigations.ConclusionsChewing gum and coffee did not improve excretion rate in this study. An effect of chewing gum could not be proven, possibly due to sample size. Since chewing gum might improve excretion rates, is cheap and has no known side effects, it needs to be considered in future bowel preparation trials for CCE.Trial registrationNCT02303756, registered on December 1st 2014.

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