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Can the application of graphene oxide contribute to the fight against COVID-19? Antiviral activity, diagnosis and prevention

  • Rhazouani, Asmaa1, 2, 3
  • Aziz, Khalid4
  • Gamrani, Halima2
  • Gebrati, Lhoucine5
  • Uddin, Md Sahab6, 7
  • Faissal, Aziz1, 3
  • 1 Laboratory of Water, Biodiversity & Climate Change, Faculty of Sciences Semlalia, Cadi Ayyad University, B.P. 2390, 40000, Marrakech, Morocco
  • 2 orocco
  • 3 National Centre for Studies and Research on Water and Energy (CNEREE), Faculty of Technical Sciences, Cadi Ayyad University, B.P 511, 40000, Marrakech, Morocco
  • 4 Materials, Catalysis and Valorization of Natural Resources, Faculty of Sciences, University Ibn Zohr, BP 8106, Agadir, Morocco
  • 5 Laboratory of Materials, Processes, Environment and Quality, Cadi Ayyad University, BP 63, 46000, Safi, Morocco
  • 6 Department of Pharmacy, Southeast University, Dhaka, Bangladesh
  • 7 Pharmakon Neuroscience Research Network, Dhaka, Bangladesh
Published Article
Current Research in Pharmacology and Drug Discovery
Published by Elsevier B.V.
Publication Date
Oct 05, 2021
DOI: 10.1016/j.crphar.2021.100062
PMCID: PMC8491929
PubMed Central
  • Article


COVID-19 is an infectious disease that affects the respiratory system and is caused by the novel coronavirus SARS-CoV-2. It was first reported in Wuhan, China, on December 31, 2019, and has affected the entire world. This pandemic has caused serious health, economic and social problems. In this situation, the only solution to combat COVID-19 is to accelerate the development of antiviral drugs and vaccines to mitigate the virus and develop better antiviral methods and excellent diagnostic and prevention techniques. With the development of nanotechnology, nanoparticles are being introduced to control COVID-19. Graphene oxide (GO), an oxidized derivative of graphene, is currently used in the medical field to treat certain diseases such as cancer. It is characterized by very important antiviral properties that allow its use in treating certain infectious diseases. The GO antiviral mechanism is discussed by the virus inactivation and/or the host cell receptor or by the physicochemical destruction of viral species. Moreover, the very high surface/volume ratio of GO allows the fixation of biomolecules by simple absorption. This paper summarizes the different studies performed on GO's antiviral activities and discusses GO-based biosensors for virus detection and approaches for prevention.

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