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Can alpha-glucosidase inhibitors reduce the dosage of sulphonylurea compounds needed by patients with non-insulin-dependent diabetes mellitus?

Authors
  • Okada, S
  • Ishii, K
  • Tanokuchi, S
  • Hamada, H
  • Ichiki, K
  • Ota, Z
Type
Published Article
Journal
The Journal of international medical research
Publication Date
Jan 01, 1995
Volume
23
Issue
6
Pages
502–507
Identifiers
PMID: 8746620
Source
Medline
License
Unknown

Abstract

The effects of treatment with an alpha-glucosidase inhibitor and a reduced dose of sulphonylurea were investigated in patients with non-insulin-dependent diabetes mellitus who had previously been treated with sulphonylurea compounds but who were hypoglycaemic at times. Treatment with a daily dose of 0.6 mg alpha-glucosidase inhibitor and a reduced dose of the previously used sulphonylurea compound for 4 weeks did not significantly affect the glycosylated haemoglobin level. The post-prandial blood-glucose concentration of the patients was unchanged after treatment compared with its value immediately before treatment but differed significantly compared with the value 4 weeks before treatment (P < 0.03); it was considered likely that this change was due to a seasonal increase in calorie intake at the end of the treatment period. Symptoms related to hypoglycaemia disappeared in all of the treated patients.

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