Affordable Access

Access to the full text

Campylobacter jejuni from Canine and Bovine Cases of Campylobacteriosis Express High Antimicrobial Resistance Rates against (Fluoro)quinolones and Tetracyclines

Authors
  • Moser, Sarah1
  • Seth-Smith, Helena2, 3
  • Egli, Adrian2, 3
  • Kittl, Sonja1
  • Overesch, Gudrun1
  • 1 (S.K.)
  • 2 (A.E.)
  • 3 Division of Clinical Bacteriology and Mycology, University Hospital Basel, 4001 Basel, Switzerland
Type
Published Article
Journal
Pathogens
Publisher
MDPI
Publication Date
Aug 23, 2020
Volume
9
Issue
9
Identifiers
DOI: 10.3390/pathogens9090691
PMID: 32842457
PMCID: PMC7558055
Source
PubMed Central
Keywords
License
Green

Abstract

Campylobacter ( C. ) spp. from poultry is the main source of foodborne human campylobacteriosis, but diseased pets and cattle shedding Campylobacter spp. may contribute sporadically as a source of human infection. As fluoroquinolones are one of the drugs of choice for the treatment of severe human campylobacteriosis, the resistance rates of C. jejuni and C. coli from poultry against antibiotics, including fluoroquinolones, are monitored within the European program on antimicrobial resistance (AMR) in livestock. However, much less is published on the AMR rates of C. jejuni and C. coli from pets and cattle. Therefore, C. jejuni and C. coli isolated from diseased animals were tested phenotypically for AMR, and associated AMR genes or mutations were identified by whole genome sequencing. High rates of resistance to (fluoro)quinolones (41%) and tetracyclines (61.1%) were found in C. jejuni (n = 29/66). (Fluoro)quinolone resistance was associated with the known point mutation in the quinolone resistance-determining region (QRDR) of gyrA , and tetracycline resistance was mostly caused by the tet(O) gene. These high rates of resistance, especially to critically important antibiotics in C. jejuni and C. coli , are worrisome not only in veterinary medicine. Efforts to preserve the efficacy of important antimicrobial treatment options in human and veterinary medicine have to be strengthened in the future.

Report this publication

Statistics

Seen <100 times