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cAMP-dependent post-translational modification of neuronal nitric oxide synthase neuroprotects penile erection in rats.

Authors
  • Karakus, Serkan1
  • Musicki, Biljana1
  • La Favor, Justin D1
  • Burnett, Arthur L1
  • 1 The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Type
Published Article
Journal
British Journal of Urology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Dec 01, 2017
Volume
120
Issue
6
Pages
861–872
Identifiers
DOI: 10.1111/bju.13981
PMID: 28782252
Source
Medline
Keywords
License
Unknown

Abstract

Collectively, BCNI impairs nNOS function in the penis and MPG by mechanisms involving its phosphorylation and uncoupling in association with increased oxidative stress, resulting in erectile dysfunction. PKA activation by colforsin reverses these molecular changes and preserves penile erection in the face of BCNI.

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