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CAM-DR: Mechanisms, Roles and Clinical Application in Tumors

  • Huang, Yuejiao1, 2
  • Wang, Yuchan3
  • Tang, Jie3
  • Qin, Shiyi1, 4
  • Shen, Xianjuan4
  • He, Song5
  • Ju, Shaoqing1, 4
  • 1 Medical School, Nantong University, Nantong , (China)
  • 2 Department of Medical Oncology, Affiliated Tumor Hospital of Nantong University, Nantong , (China)
  • 3 Department of Pathogenic Biology, School of Medicine, Nantong University, Nantong , (China)
  • 4 Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong , (China)
  • 5 Department of Pathology, Affiliated Tumor Hospital of Nantong University, Nantong , (China)
Published Article
Frontiers in Cell and Developmental Biology
Frontiers Media SA
Publication Date
Jul 06, 2021
DOI: 10.3389/fcell.2021.698047
  • Cell and Developmental Biology
  • Review


Despite the continuous improvement of various therapeutic techniques, the overall prognosis of tumors has been significantly improved, but malignant tumors in the middle and advanced stages still cannot be completely cured. It is now evident that cell adhesion-mediated resistance (CAM-DR) limits the success of cancer therapies and is a great obstacle to overcome in the clinic. The interactions between tumor cells and extracellular matrix (ECM) molecules or adjacent cells may play a significant role in initiating the intracellular signaling pathways that are associated with cell proliferation, survival upon binding to their ligands. Recent studies illustrate that these adhesion-related factors may contribute to the survival of cancer cells after chemotherapeutic therapy, advantageous to resistant cells to proliferate and develop multiple mechanisms of drug resistance. In this review, we focus on the molecular basis of these interactions and the main signal transduction pathways that are involved in the enhancement of the cancer cells’ survival. Furthermore, therapies targeting interactions between cancer cells and their environment to enhance drug response or prevent the emergence of drug resistance will also be discussed.

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