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Calreticulin mediates anesthetic sensitivity in Drosophila melanogaster.

Authors
  • Gamo, Sumiko
  • Tomida, Junya
  • Dodo, Katsuyuki
  • Keyakidani, Dai
  • Matakatsu, Hitoshi
  • Yamamoto, Daisuke
  • Tanaka, Yoshiharu
Type
Published Article
Journal
Anesthesiology
Publication Date
Oct 01, 2003
Volume
99
Issue
4
Pages
867–875
Identifiers
PMID: 14508319
Source
Medline
License
Unknown

Abstract

ethas311 is a mutation of low expression of the Drosophila calreticulin gene. The authors demonstrated that hypersensitivity to diethylether and resistance to isoflurane are associated with low expression of the gene. In Drosophila, calreticulin seems to mediate these anesthetic sensitivities, and it is a possible target for diethylether and isoflurane, although the predicted anesthetic targets based on many studies in vitro and in vivo are the membrane proteins, such as ion channels and receptors.

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