Calreticulin mediates anesthetic sensitivity in Drosophila melanogaster.
- Published Article
- Publication Date
Oct 01, 2003
ethas311 is a mutation of low expression of the Drosophila calreticulin gene. The authors demonstrated that hypersensitivity to diethylether and resistance to isoflurane are associated with low expression of the gene. In Drosophila, calreticulin seems to mediate these anesthetic sensitivities, and it is a possible target for diethylether and isoflurane, although the predicted anesthetic targets based on many studies in vitro and in vivo are the membrane proteins, such as ion channels and receptors.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/14508319