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Calorie Restriction Increases the Number of Competing Stem Cells and Decreases Mutation Retention in the Intestine

Authors
  • Bruens, Lotte1, 2
  • Ellenbroek, Saskia Inge Johanna1
  • Suijkerbuijk, Saskia Jacoba Elisabeth1
  • Azkanaz, Maria1
  • Hale, Alexander James3
  • Toonen, Pim3
  • Flanagan, Dustin James4
  • Sansom, Owen James4, 5
  • Snippert, Hugo Johannes2
  • van Rheenen, Jacco1, 2
  • 1 Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, Amsterdam 1066 CX, the Netherlands
  • 2 Molecular Cancer Research, Center for Molecular Medicine, Oncode Institute, University Medical Center Utrecht, Utrecht 3584 CG, the Netherlands
  • 3 Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht 3584 CT, the Netherlands
  • 4 CRUK Beatson Institute, Glasgow G61 1BD, UK
  • 5 Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Jul 21, 2020
Volume
32
Issue
3
Identifiers
DOI: 10.1016/j.celrep.2020.107937
PMID: 32698002
PMCID: PMC7383228
Source
PubMed Central
Keywords
License
Unknown

Abstract

Calorie restriction increases the number of stem cells in intestinal crypts. Bruens et al. show that this increase results in stronger stem cell competition. Consequently, mutated stem cells encounter more wild-type competitors, which decreases the chance that these mutated stem cells are retained in the intestinal epithelium.

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