Affordable Access

deepdyve-link
Publisher Website

Callosal tissue loss in multiple system atrophy--a one-year follow-up study.

Authors
  • Minnerop, Martina
  • Lüders, Eileen
  • Specht, Karsten
  • Ruhlmann, Jürgen
  • Schimke, Nicole
  • Thompson, Paul M
  • Chou, Yi Y
  • Toga, Arthur W
  • Abele, Michael
  • Wüllner, Ullrich
  • Klockgether, Thomas
Type
Published Article
Journal
Movement Disorders
Publisher
Wiley (John Wiley & Sons)
Publication Date
Nov 15, 2010
Volume
25
Issue
15
Pages
2613–2620
Identifiers
DOI: 10.1002/mds.23318
PMID: 20623690
Source
Medline
License
Unknown

Abstract

Multiple system atrophy (MSA) is a neurodegenerative disease not only affecting the basal ganglia, brainstem, cerebellum, and intermediolateral cell columns of the spinal cord but also the cerebral cortex. Clinically, cerebellar (MSA-C) and parkinsonian variants of MSA (MSA-P) are distinguished. We investigated 14 MSA patients (10 MSA-C, 4 MSA-P, men: 7, women: 7; age: 61.1 ± 3.3 years) and 14 matched controls (men: 7, women: 7; age: 58.6 ± 5.1 years) with voxel-based morphometry (VBM) to analyze gray and white matter differences both at baseline and at follow-up, 1 year later. Baseline comparisons between patients and controls confirmed significantly less gray matter in MSA in the cerebellum and cerebral cortex, and significantly less white matter in the cerebellar peduncles and brainstem. Comparisons of tissue-loss profiles (i.e., baseline versus follow-up) between patients and controls, revealed white matter reduction in MSA along the middle cerebellar peduncles, reflecting degeneration of the ponto-cerebellar tract as a particularly prominent and progressive morphological alteration in MSA. Comparisons between baseline and follow-up, separately performed in patients and controls, revealed additional white matter reduction in MSA along the corpus callosum at follow-up. This was replicated through additional shape-based analyses indicating a reduced callosal thickness in the anterior and posterior midbody, extending posteriorly into the isthmus. Callosal atrophy may possibly reflect a disease-specific pattern of neurodegeneration and cortical atrophy, fitting well with the predominant impairment of motor functions in the MSA patients.

Report this publication

Statistics

Seen <100 times