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Calf vein thrombosis outcomes comparing patients with and without cancer.

Authors
  • Pasha, Ahmed K1, 2
  • Kuczmik, Wiktoria1
  • Wysokinski, Waldemar E1, 2
  • Casanegra, Ana I1, 2
  • Houghton, Damon1, 2
  • Vlazny, Danielle T1, 2
  • Mertzig, Abigail1, 2
  • Hirao-Try, Yumiko1, 2
  • White, Launia3
  • Hodge, David3
  • McBane Ii, Robert4, 5
  • 1 Gonda Vascular Center, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
  • 2 Cardiovascular Department, Mayo Clinic, Rochester, MN, 55905, USA.
  • 3 Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA.
  • 4 Gonda Vascular Center, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. [email protected]
  • 5 Cardiovascular Department, Mayo Clinic, Rochester, MN, 55905, USA. [email protected]
Type
Published Article
Journal
Journal of Thrombosis and Thrombolysis
Publisher
Springer-Verlag
Publication Date
May 01, 2021
Volume
51
Issue
4
Pages
1059–1066
Identifiers
DOI: 10.1007/s11239-021-02390-x
PMID: 33538988
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Distal or calf deep vein thrombosis (DVT) are said to have low rates of propagation, embolization, and recurrence. The objective of this study was to determine outcomes among cancer patients with calf DVT compared to those without cancer. Consecutive patients with ultrasound confirmed acute calf DVT (3/1/2013-8/10/2019) were assessed for venous thromboembolism (VTE) recurrence and bleeding outcomes compared by cancer status. There were 830 patients with isolated calf DVT; 243 with cancer and 587 without cancer. Cancer patients were older (65.9 ± 11.4 vs. 62.0 ± 15.9 years; p = 0.006), with less frequent recent hospitalization (31.7% vs. 48.0%; p < 0.001), surgery (30.0% vs. 38.0%; p = 0.03), or trauma (3.7% vs. 19.9%; p < 0.001). The four most common cancers included hematologic malignancies (20.6%), lung (11.5%), gastrointestinal (10.3%), and ovarian/GYN (9.1%). Nearly half of patients had metastatic disease (43.8%) and 57% were receiving chemotherapy. VTE recurrence rates were similar for patients with (7.1%) and without cancer (4.0%; p = 0.105). Major bleeding (6.3% vs. 2.3%; p = 0.007) were greater for cancer patients while clinical relevant non major bleeding rates did not differ (7.1% vs. 4.6%; p = 0.159). In this retrospective analysis, cancer patients with calf DVT have similar rates of VTE recurrence but higher major bleeding outcomes compared to patients without cancer.

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